Lisebelisoa tsa Bohlokoa tsa Nucleosides tse Fetotsoeng

Selelekela

Li-nucleosides, li-block tsa nucleic acids (DNA le RNA), li phetha karolo ea bohlokoa linthong tsohle tse phelang. Ka ho fetola limolek'hule tsena, bo-rasaense ba notlollotse lintho tse ngata tse ka sebelisoang lipatlisisong le bongakang. Sehloohong sena, re tla hlahloba tse ling tsa lisebelisoa tsa bohlokoa tsali-nucleoside tse fetotsoeng.

Karolo ea Nucleosides e Fetoletsoeng

Li-nucleoside tse fetotsoeng li entsoe ka ho fetola sebopeho sa li-nucleoside tsa tlhaho, tse kang adenosine, guanosine, cytidine le uridine. Liphetoho tsena li ka kenyelletsa liphetoho motheong, tsoekere, kapa ka bobeli. Sebopeho se fetotsoeng se ka fana ka thepa e ncha ho nucleoside e fetotsoeng, ea etsa hore e tšoanelehe bakeng sa likopo tse fapaneng.

Lisebelisoa tsa Bohlokoa

Ho Fumana Lithethefatsi:

Li-anticancer agents: Li-nucleoside tse fetotsoeng li 'nile tsa sebelisoa ho hlahisa mefuta e mengata ea meriana e thibelang mofetše. Ka mohlala, li ka etsoa ho thibela DNA synthesis kapa ho lebisa lisele tse itseng tsa mofetše.

Lithethefatsi tse thibelang kokoana-hloko: Li-nucleoside tse fetotsoeng li sebelisoa ho etsa meriana e thibelang kokoana-hloko e ka thibelang ho ikatisa ha kokoana-hloko. Mohlala o tsebahalang haholo ke ts'ebeliso ea li-nucleoside tse fetotsoeng ho liente tsa COVID-19 mRNA.

Meriana e thibelang likokoana-hloko: Li-nucleoside tse fetotsoeng le tsona li bontšitse tšepo tlhahisong ea lithibela-mafu tse ncha.

Boenjiniere ba Liphatsa tsa lefutso:

Liente tsa mRNA: Li-nucleoside tse fetotsoeng ke likarolo tsa bohlokoa tsa liente tsa mRNA, kaha li ka matlafatsa botsitso le tšireletso ea 'mele ea mRNA.

Li-oligonucleotides tsa Antisense: Limolek'hule tsena, tse etselitsoeng ho tlama ka tatellano e itseng ea mRNA, li ka fetoloa ho ntlafatsa botsitso le ho khetheha ha tsona.

Phekolo ea liphatsa tsa lefutso: Li-nucleoside tse fetotsoeng li ka sebelisoa ho theha li-oligonucleotide tse fetotsoeng bakeng sa lits'ebetso tsa kalafo ea lefutso, joalo ka ho lokisa liphoso tsa lefutso.

Lisebelisoa tsa Lipatlisiso:

Nucleic acid probes: Li-nucleoside tse fetotsoeng li ka kenyelletsoa ho li-probes tse sebelisoang mekhoeng e kang fluorescence in situ hybridization (FISH) le tlhahlobo ea microarray.

Li-Aptamers: Li-nucleic acid tsena tsa stranded single-stranded nucleic acid li ka fetoloa hore li tlamelle lipheo tse itseng, joalo ka liprotheine kapa limolek'hule tse nyane, 'me li na le ts'ebeliso ho tlhahlobo le kalafong.

Melemo ea Nucleosides e fetotsoeng

Botsitso bo ntlafetseng: Li-nucleosides tse fetotsoeng li ka matlafatsa botsitso ba li-nucleic acid, tsa etsa hore li se ke tsa senyeha habonolo ke li-enzyme.

Keketseho e ikhethang: Liphetoho li ka ntlafatsa ho hlaka ha litšebelisano tsa nucleic acid, tsa etsa hore limolek'hule tse khethehileng tsa baeloji li shejoe ka nepo haholoanyane.

Tšebeliso e ntlafalitsoeng ea lisele: Li-nucleoside tse fetotsoeng li ka etsoa ho ntlafatsa ts'ebeliso ea lisele tsa bona, ho eketsa katleho ea tsona lits'ebetsong tsa phekolo.

Qetello

Li-nucleoside tse fetotsoeng li fetotse mekhoa e fapa-fapaneng, ho tloha ho sibollo ea lithethefatsi ho ea ho boenjiniere ba liphatsa tsa lefutso. Ho feto-fetoha ha tsona le bokhoni ba ho lokisetsoa lits'ebetso tse ikhethileng ho li etsa lisebelisoa tsa bohlokoa bakeng sa bafuputsi le lingaka. Ha kutloisiso ea rona ea k'hemistri ea nucleic acid e ntse e hola, re ka lebella ho bona lits'ebetso tse ncha tsa li-nucleoside tse fetotsoeng nakong e tlang.