Sulfadiazine sodium is a medium-acting sulfonamide antibiotic that has antibacterial effects on many Gram-positive and Gram-negative bacteria. E na le litlamorao tsa antibacterial ho Staphylococcus aureus e sa hlahiseng li-enzyme, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella, Neisseria gonorrhoeae, Neisseria meningitidis, le Haemophilus influenzae. In addition, it is also active against Chlamydia trachomatis, Nocardia asteroides, Plasmodium, and Toxoplasma in vitro. The antibacterial activity of this product is the same as that of sulfamethoxazole. However, in recent years, bacterial resistance to this product has increased, especially Streptococcus, Neisseria, and Enterobacteriaceae.