2-methyl-5-nitroimidazole
Lintlha tsa Motheo:
Lebitso la lik'hemik'hale: 2-methyl-5-nitroimidazole;
Lebitso la Senyesemane: 2-Methyl-5-nitroimidazole;
Nomoro ea CAS: 88054-22-2
Foromo ea molek'hule: C4H5N3O2
Boima ba molek'hule: 127.1
Nomoro ea EINECS: 618-108-7
Foromo ea sebopeho:
Likarolo tse amanang: lisebelisoa tse tala; Li-intermediates tsa meriana; Lisebelisoa tse tala tsa meriana.
Boima: 1.4± 0.1g /cm3
Sebaka se belang :399.5±15.0 °C ho 760 mmHg
Sebaka se qhibilihang: 252-254ºC
Sebaka sa ho benya:195.4±20.4°C
Boima bo nepahetseng :127.038177
PSA:74.50000 LogP:-0.10
Ponahalo: Khalase e tšoeu
Khatello ea mouoane: 0.0±0.9 mmHg ho 25°C
Lethathamo la refractive: 1.592
Maemo a polokelo: e tiisitsoe sebakeng se phodileng le se omileng sa 0-6 ºC
Botsitso: e ke ke ea bola ha e sebelisoa le ho bolokoa ho latela melaoana.
| tlhaloso | unit | maemo |
| Ponahalo | Joalo ka phofo e tšoeu kapa e mosehla | |
| Litaba | % | ≥99% |
| Mongobo | % | ≤0.3 |
| Sulfate | % | ≤0.3 |
Haholo-holo sebelisoa ka synthesis ea metronidazole, dimetazole le lithethefatsi tse ling intermediates.
E fumanoa ka nitrate ea 2-methylimidazole. Kenya sulfuric acid, 2-methylimidazole le sodium sulfate ka pitseng ea reaction, hlohlelletsa le mocheso, eketsa asiti ea nitric ho 150-160 ℃, kopanya, latela karabelo ea casket bakeng sa hora e le 'ngoe. Tlosa mocheso ho 140 ℃ ka tlase, ka mor'a ho eketsa metsi ka metsi a ammonia ho fetola pH ho 3.5-4, crystallization. Senya, hlatsoa ho ea ho se nke lehlakore, se omeletseng, 2-methyl-5-nitroimidazole.
25k kraft pampiri mokotla kapa e lohiloeng (58×110) lined le mokotla polasetiki, 250kg diyantle setshelo mokotla (100×80); Ho latela litlhoko tsa bareki;
Poloko e tiisitsoeng, e bolokiloeng sebakeng se pholileng, se lefifi, se omeletseng, polokelo le lipalangoang e lokela ho ba leseli, ho thibela tšenyo le mongobo, ho thibetsoe ka thata le lithethefatsi tse tsoakiloeng.
Mokhoa oa tlhahiso: E fumanoa ka nitration ea 2-methylimidazole. Kenya sulfuric acid, 2-methylimidazole le sodium sulfate ka pitseng ea reaction, hlohlelletsa le mocheso, eketsa asiti ea nitric ho 150-160 ℃, kopanya, latela karabelo ea casket bakeng sa hora e le 'ngoe. Tlosa mocheso ho 140 ℃ ka tlase, ka mor'a ho eketsa metsi ka metsi a ammonia ho fetola pH ho 3.5-4, crystallization. Senya, hlatsoa ho ea ho se nke lehlakore, se omeletseng, 2-methyl-5-nitroimidazole.
